Download S.E.M.I. – Side Effects May Include...

S.E.M.I. – Side Effects May Include... Game Details

Title: S.E.M.I. – Side Effects May Include...
Genre: Action, Indie
Developer: Two Horn Unicorn
Publisher: Two Horn Unicorn
Release Date: 20 November 2025
Store: Steam
Game Releasers: P2P

About S.E.M.I. – Side Effects May Include... Game

Escape a chaotic clinic with friends in S.E.M.I., a cooperative action game where experimental drugs grant unpredictable powers and hilarious side effects! Out November 20, 2025.

S.E.M.I.: Side Effects May Include... plunges players into the chaotic world of a peculiar clinic, where experimentation runs rampant and the lines between sanity and madness blur. This cooperative action game, designed for 1 to 4 players, casts you and your companions as patients caught in a web of medical trials and desperate escape plans. The core concept revolves around embracing the unpredictable – ingesting experimental drugs that bestow extraordinary powers, but at a steep cost. These powers manifest with unpredictable side effects, turning each playthrough into a unique and often hilarious struggle for survival.

The narrative premise of S.E.M.I. is deceptively simple: escape. However, the path to freedom is paved with challenges that demand teamwork, communication, and a healthy dose of reckless abandon. Players must navigate the labyrinthine corridors of the clinic, facing off against hostile staff, deranged fellow patients, and the ever-present threat of their own unraveling minds. The true beauty of S.E.M.I. lies in its emergent gameplay, where the interplay of randomized events and volatile drug effects creates a dynamic and unpredictable experience.

The reliance on communication is paramount, as players must coordinate their actions to overcome obstacles and exploit the unique abilities – and weaknesses – granted by the experimental concoctions. Voice chat becomes an essential tool for survival, allowing players to strategize, warn each other of impending dangers, and, perhaps most importantly, share the laughter born from the sheer absurdity of the situation. Planning and executing acts of sabotage against the clinic become crucial to evening the odds, requiring players to think creatively and utilize their environment to their advantage. Success hinges on the ability to adapt to the ever-shifting landscape of the clinic and the unpredictable nature of their own powers.

At the heart of S.E.M.I.'s gameplay are the experimental drugs, each granting a distinct superpower while simultaneously inflicting a debilitating side effect. These powers are not mere stat boosts or simple combat enhancements; they are transformative abilities that fundamentally alter the way players interact with the world. "Bipolar Force," for example, can transform a player into an invulnerable behemoth one moment, only to revert them into a helpless ragdoll the next.

"Laser Astigmatism" grants the power of a laser beam, but accompanied by a disorienting double vision, making aiming a chaotic exercise in guesswork. “Stendhal Syndrome,” triggered by viewing paintings, induces fits of hysterical destruction, turning the player into a walking wrecking ball. “Alice’s Syndrome” causes unpredictable shifts in size, shrinking players to minuscule proportions or expanding them to gigantic heights, forcing them to constantly adjust their tactics and positioning.

The randomness of these powers and their corresponding side effects adds a layer of comedic chaos to the gameplay, turning what might have been a straightforward action game into a hilarious experiment in cooperative madness. Players must learn to embrace the unpredictability, adapting their strategies on the fly and finding creative ways to utilize their powers – and mitigate their weaknesses – to overcome the challenges that lie ahead. The constant potential for things to go hilariously wrong is a core element of S.E.M.I.'s appeal.

Adding to the challenge is the ever-present threat of madness. Prolonged exposure to the experimental drugs and the stressful environment of the clinic can push players to the brink of sanity. When madness sets in, players lose control of their characters, who begin acting erratically, running, jumping, and fighting uncontrollably. Their abilities become even more unpredictable, turning them into a liability to their team. The only way to regain control is to ingest more pills, perpetuating the cycle of experimentation and further blurring the lines between reality and delusion.

The clinic itself is a character in S.E.M.I., a constantly shifting landscape of randomly generated rooms filled with deadly hazards and unexpected surprises. Gravity shifts, traps spring, walls move, and other environmental hazards conspire to thwart the players' escape attempts. No two playthroughs are ever quite the same, as the layout of the clinic and the placement of traps and obstacles are constantly randomized. This ensures a high degree of replayability, as players are always encountering new challenges and adapting to unfamiliar environments.

The procedurally generated environments further contribute to the game's unpredictable nature, forcing players to think on their feet and adapt their strategies to the specific layout of each level. The interplay between the randomized rooms and the randomized drug effects creates a dynamic and constantly evolving gameplay experience that keeps players on their toes. The game encourages players to explore the environment, discover hidden pathways, and utilize their surroundings to their advantage, adding another layer of depth to the gameplay.

Adding a layer of levity to the grim setting, S.E.M.I. rewards successful escapes with a darkly humorous medical report, detailing the player's actions and offering a satirical diagnosis. These reports often poke fun at the player's behavior during the escape, highlighting the absurdity of the situation and the lengths they went to survive. A report might state, "The patient was stable until he started hitting the guards with a bottle. Diagnosis: Overmotivation," or offer another equally absurd assessment of their mental state.

Beyond the core gameplay, S.E.M.I. offers a system of unlockable costumes and decorations, allowing players to customize their characters and add a touch of personal style to their escape attempts. These cosmetic items provide a sense of progression and accomplishment, encouraging players to keep playing and experimenting with different strategies. The ability to personalize their characters also adds another layer of enjoyment to the game, allowing players to express their creativity and humor through their in-game avatars. Ultimately, S.E.M.I. is a game about embracing the chaos, laughing in the face of adversity, and forging unforgettable memories with friends in a world where the only certainty is the unpredictability of side effects.

S.E.M.I. – Side Effects May Include... Key Features

• * 💊 Pop experimental pills and unleash insane superpowers… with unpredictable side effects!
• * 🤝 Team up with up to 3 friends in chaotic cooperative gameplay!
• * 🗣️ Coordinate your escape with voice chat and hilarious sabotage!
• * 🤪 Brace yourself for madness! Go crazy, lose control, and desperately pop more pills!
• * 🚪 Navigate randomly generated, trap-filled, gravity-bending locations!
• * 🤣 Earn epic medical reports that hilariously diagnose your descent into madness!
• * 🎭 Unlock stylish costumes and decorations for your next fashionable escape!
• * 🤯 Can you and your friends escape the mental hospital… or will you lose your minds first?

System Requirements for S.E.M.I. – Side Effects May Include...

To run S.E.M.I. – Side Effects May Include..., your system needs to meet certain specifications. At a minimum, you'll require Windows 10, an Intel Core i5 or Ryzen series processor, 8 GB of RAM, a GTX 960 or AMD R9 290 graphics card, DirectX Version 11 compatibility, and 3 GB of available storage space. For an optimal experience, it's recommended to use Windows 11, an Intel Core i7 or Ryzen series processor, 8 GB of RAM, a GTX 1660 or RX6600 graphics card, DirectX Version 12 compatibility, and the same 3 GB of storage space.

• OS: Windows 10
• Processor: Intel Core i5 series or Ryzen series
• Memory: 8 GB RAM
• Graphics: GTX 960 or AMD R9 290
• DirectX: Version 11
• Storage: 3 GB available space

• OS: Windows 11
• Processor: Intel Core i7 series or Ryzen series
• Memory: 8 GB RAM
• Graphics: GTX 1660 or RX6600
• DirectX: Version 12
• Storage: 3 GB available space

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